We face the greatest environmental challenges ever relating to climate change, biodiversity, land use, and more. Humans are driving 1 million species to extinction, according to a report by the UN-backed Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services. Some $44 trillion of annual global economic product that depend on nature are in jeopardy. Fires have ravaged large swathes of the Amazon—Brazil and Bolivia in particular—and Australia.

In 2003, a scabies skin disease outbreak affecting mountain gorillas in Bwindi Impenetrable National Park was traced to people living around the national park—people with limited access to basic health and social services. To protect the people and wildlife of this special park, we launched Conservation Through Public Health (CTPH), an NGO that promotes biodiversity conservation by enabling people, gorillas, and other wildlife to coexist harmoniously through improved health and wellbeing.

Last summer, I stood on a cliff 100 feet above the Madre De Dios River, in Southern Peru near the Bolivian border, to watch the rosy gift of an Amazon sunset. It was quiet, in a tropical rainforest way, with the light clamor of parrots, macaws, and cicadas. Then, a peke-peke motorized canoe broke through the soft din. It arrived from the east, carrying a new supply of diesel fuel for the gold miners who were prepping the generator that would operate a suction-pump and dredge for gold across the river and around the bend. Before nightfall, the fuel ignited the baritone of a diesel generator. It moaned all night and all day, barely stopping. In subsequent days, instead of a light clamor of birds and primates, the thrum of a gold mining operation seemed like all I could hear.

Since the dawn of the Industrial Revolution, humans have so vastly altered Earth’s systems that we’re now in the midst of what many are calling the Anthropocene Epoch. Human activity has become the dominant influence on climate and the environment, inflicting changes that may persist for millennia.

We are razing the planet’s last intact wild lands, degrading, deforesting, carving up, and destroying huge swathes of habitat. We’re overfishing and poisoning our rivers and oceans. We continue to pump greenhouse gases into the atmosphere, raising CO2 levels and hastening climatic changes that are already affecting all life on Earth.

“Having a planet that is suitable for us has taken a very long time, like four and a half billion years,” said Sylvia Earle, Explorer in Residence at the National Geographic Society, in a podcast interview with Ambassador David Balton before a recent Wilson Center event on marine protected areas. “It’s taken us about four and a half decades to significantly unravel, deplete, [and] modify those precious systems that really have little margin of error.”