“To attack the most vulnerable—babies, children, pregnant women, and those already suffering from illness and disease, and health workers risking their own lives to save lives—is an act of unconscionable cruelty,” says a Joint Statement from UNICEF, UNFPA, and WHO in response to the ongoing war in Ukraine. To monitor human rights abuses such as this and improve human rights conditions around the world, the United Nations (UN) General Assembly established the Universal Periodic Review (UPR) in 2006. The UPR produces purposeful engagement by all 193 UN member states participating in the periodic reviews. Despite the UPR’s potential to advance human rights—and by extension improve human security—this novel human rights mechanism receives little attention among scholars and policymakers. This lack of interest in the UPR needs to change. More research could shed light on its role in improving human rights outcomes in conflict-free countries as well as in countries experiencing conflict like in Ukraine, Syria, and Ethiopia.