No country has escaped the setbacks caused by COVID-19, but impacts on low-income countries are proving far worse. The World Bank estimates the pandemic and the actions necessary to contain it will drive 150 million people globally into extreme poverty. Post-pandemic, there will likely be long-term effects. Even with this grim reality, there is hope. Governments and international development organizations have accumulated a wealth of knowledge about what works to reduce poverty and increase economic activity. As the Biden administration and other actors work to build a post-pandemic environment, key lessons can be drawn from this knowledge to inform recovery efforts.